ICD-9-CM diagnosis code (retired)
249.21 — Secondary diabetes mellitus with hyperosmolarity, uncontrolled
About ICD-9-CM 249.21
249.21 is an ICD-9-CM diagnosis code for secondary diabetes mellitus with hyperosmolarity, uncontrolled. ICD-9-CM was retired for U.S. claims on October 1, 2015, when ICD-10-CM took over.
The CMS General Equivalence Mappings translate it to 3 ICD-10-CM codes, such as E08.01 (Diabetes mellitus due to underlying condition with hyperosmolarity with coma), E08.65 (Diabetes mellitus due to underlying condition with hyperglycemia) and E09.01 (Drug or chemical induced diabetes mellitus with hyperosmolarity with coma). All of these are approximate matches, so review the record to pick the right one. Some mappings are combinations: more than one ICD-10 code is needed to fully express the ICD-9 code.
ICD-10-CM equivalents
- E08.01Diabetes mellitus due to underlying condition with hyperosmolarity with comaapproximate · combination (scenario 1, choice 1)
- E08.65Diabetes mellitus due to underlying condition with hyperglycemiaapproximate · combination (scenario 1, choice 2)
- E09.01Drug or chemical induced diabetes mellitus with hyperosmolarity with comaapproximate · combination (scenario 1, choice 1)
Common questions about 249.21
GEMs are a translation aid, not a substitute for coding from the record. The 2027 ICD-10 code set has changed since the last GEMs release in 2018. Page updated September 29, 2026.