ICD-10-PCS 2027 procedure code

3E0K80MIntroduction of Antineoplastic, Monoclonal Antibody, into Genitourinary Tract, Via Natural or Artificial Opening Endoscopic

✓ Valid for 2027

Short description: Introduction of Antneo, Moncln Ab, into GU Tract, Endo

Code last changed in FY2022 (effective October 1, 2021). Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E0K80M

3E0K80M is the ICD-10-PCS code for a introduction procedure on the genitourinary tract using a via natural or artificial opening endoscopic approach with antineoplastic (qualifier: monoclonal antibody). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

In plain terms, this corresponds to injection or infusion of biological response modifier [BRM] as an antineoplastic agent, the ICD-9-CM procedure title it maps to (99.28).

For a different body part, codes include 3E0E80M (products of conception), 3E0F80M (respiratory tract), 3E0G80M (upper GI), 3E0H80M (lower GI), 3E0J80M (biliary and pancreatic tract), 3E0N80M (male reproductive) and 1 more.

The same procedure with a different approach is coded 3E0K30M (percutaneous) and 3E0K70M (via natural or artificial opening).

It doesn't appear in the MS-DRG procedure index, so on its own it doesn't change the DRG assignment.

It has been valid since ICD-10-PCS took effect on October 1, 2015.

What each character means

1. Section: 3Administration
2. Body System: EPhysiological Systems and Anatomical Regions
3. Operation: 0Introduction
Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products
4. Body System / Region: KGenitourinary Tract
5. Approach: 8Via Natural or Artificial Opening Endoscopic
Entry of instrumentation through a natural or artificial external opening to reach and visualize the site of the procedure
6. Substance: 0Antineoplastic
Includes: Amivantamab Monoclonal Antibody; Lurbinectedin; RYBREVANT (tm) (Amivantamab Monoclonal Antibody); ZEPZELCA(tm) (Lurbinectedin)
7. Qualifier: MMonoclonal Antibody

Other versions of this procedure

Different body system / region

Different approach

Different qualifier

ICD-9-CM equivalent

Converter →

99.28Injection or infusion of biological response modifier [BRM] as an antineoplastic agentapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
2027

FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
FY2022 (effective 10/1/2021): Title revised — was “Introduction of Monoclonal Antibody into Genitourinary Tract, Via Natural or Artificial Opening Endoscopic”

Common questions about 3E0K80M

Is 3E0K80M a valid ICD-10-PCS code for 2027?: Yes. 3E0K80M is valid for inpatient procedures from October 1, 2026 through September 30, 2027.
What is the ICD-9 procedure code for 3E0K80M?: The CMS GEMs map 3E0K80M to ICD-9-CM 99.28 (Injection or infusion of biological response modifier [BRM] as an antineoplastic agent).