ICD-10-CM 2027
ICD-10 code for Xanthoma
From the official ICD-10-CM alphabetic index entry “Xanthoma (s), xanthomatosis (primary) (familial) (hereditary)”. Page updated September 29, 2026.
About coding Xanthoma
The ICD-10-CM code for Xanthoma is E78.2 (Mixed hyperlipidemia). The official index lists 19 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E78.2.
Within E78 (disorders of lipoprotein metabolism and other lipidemias), E78.2 is specifically for mixed hyperlipidemia. Related codes cover pure hypercholesterolemia (E78.0), pure hyperglyceridemia (E78.1), Hyperchylomicronemia (E78.3), other hyperlipidemia (E78.4), hyperlipidemia, unspecified (E78.5), lipoprotein deficiency (E78.6), disorders of bile acid and cholesterol metabolism (E78.7), other disorders of lipoprotein metabolism (E78.8) and 1 more.
Don't report E78.2 together with the conditions in its Excludes1 note: cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5) and familial combined hyperlipidemia (E78.49).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific Xanthoma codes (official index)
- with
- hyperlipoproteinemia
- Type I E78.3 — Hyperchylomicronemia
- Type III E78.2 — Mixed hyperlipidemia
- Type IV E78.1 — Pure hyperglyceridemia
- Type V E78.3 — Hyperchylomicronemia
- bone (generalisata) C96.5 — Multifocal and unisystemic Langerhans-cell histiocytosis
- cerebrotendinous E75.5 — Other lipid storage disorders
- cutaneotendinous E75.5 — Other lipid storage disorders
- disseminatum (skin) E78.2 — Mixed hyperlipidemia
- eruptive E78.2 — Mixed hyperlipidemia
- hypercholesterinemic E78.00 — Pure hypercholesterolemia, unspecified
- hypercholesterolemic E78.00 — Pure hypercholesterolemia, unspecified
- hyperlipidemic E78.5 — Hyperlipidemia, unspecified
- joint E75.5 — Other lipid storage disorders
- multiple (skin) E78.2 — Mixed hyperlipidemia
- tendon (sheath) E75.5 — Other lipid storage disorders
- tubo-eruptive E78.2 — Mixed hyperlipidemia
- tuberosum E78.2 — Mixed hyperlipidemia
- tuberous E78.2 — Mixed hyperlipidemia
- verrucous, oral mucosa K13.4 — Granuloma and granuloma-like lesions of oral mucosa
Don't confuse with (Excludes1 for E78.2)
Common questions about Xanthoma ICD-10 codes
What is the ICD-10 code for Xanthoma?
- E78.2 — Mixed hyperlipidemia. More specific codes apply when the documentation supports them: E78.3, E78.2, E78.1, E78.3 and others below.
What is the ICD-10 code for bone xanthoma?
- C96.5 — Multifocal and unisystemic Langerhans-cell histiocytosis.
What is the ICD-10 code for cerebrotendinous xanthoma?
- E75.5 — Other lipid storage disorders.
What is the ICD-10 code for cutaneotendinous xanthoma?
- E75.5 — Other lipid storage disorders.
What is the ICD-10 code for disseminatum xanthoma?
- E78.2 — Mixed hyperlipidemia.
What is the ICD-10 code for eruptive xanthoma?
- E78.2 — Mixed hyperlipidemia.
What is the ICD-10 code for hypercholesterinemic xanthoma?
- E78.00 — Pure hypercholesterolemia, unspecified.
Is E78.2 billable?
- Yes. E78.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E78.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E78.2 as a principal diagnosis.
Is E78.2 a CC or MCC?
- No. E78.2 is neither a CC nor an MCC under MS-DRG v44.0.