ICD-10 code for whole chromosome trisomy

The ICD-10-CM code for whole chromosome trisomy is Q92.9 (Trisomy and partial trisomy of autosomes, unspecified). The official index lists 5 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on Q92.9.

Within Q92, choose Q92.9 (Trisomy and partial trisomy of autosomes, unspecified) only when documentation doesn't support a more specific option: whole chromosome trisomy, nonmosaicism (meiotic nondisjunction) (Q92.0), whole chromosome trisomy, mosaicism (mitotic nondisjunction) (Q92.1), partial trisomy (Q92.2), Duplications with other complex rearrangements (Q92.5), marker chromosomes (Q92.6), Triploidy and polyploidy (Q92.7) and other specified trisomies and partial trisomies of autosomes (Q92.8).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.