ICD-10-CM 2027
ICD-10 code for urea cycle metabolism disorder
Disorder of urea cycle metabolism, unspecified
From the official ICD-10-CM alphabetic index entry “Disorder (of) › urea cycle metabolism”. Page updated September 29, 2026.
About coding urea cycle metabolism disorder
The ICD-10-CM code for urea cycle metabolism disorder is E72.20 (Disorder of urea cycle metabolism, unspecified). The official index lists 5 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E72.20.
Within E72.2, choose E72.20 (Disorder of urea cycle metabolism, unspecified) only when documentation doesn't support a more specific option: Argininemia (E72.21), Arginosuccinic aciduria (E72.22), Citrullinemia (E72.23) and other disorders of urea cycle metabolism (E72.29).
Don't report E72.20 together with the conditions in its Excludes1 note: hyperammonemia-hyperornithinemia-homocitrullinemia syndrome E72.4 and transient hyperammonemia of newborn (P74.6).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
More specific urea cycle metabolism disorder codes (official index)
Don't confuse with (Excludes1 for E72.20)
Common questions about urea cycle metabolism disorder ICD-10 codes
What is the ICD-10 code for urea cycle metabolism disorder?
- E72.20 — Disorder of urea cycle metabolism, unspecified. More specific codes apply when the documentation supports them: E72.21, E72.22, E72.23, E72.4 and others below.
What is the ICD-10 code for argininemia urea cycle metabolism disorder?
- E72.21 — Argininemia.
What is the ICD-10 code for arginosuccinic aciduria urea cycle metabolism disorder?
- E72.22 — Arginosuccinic aciduria.
What is the ICD-10 code for citrullinemia urea cycle metabolism disorder?
- E72.23 — Citrullinemia.
What is the ICD-10 code for ornithine transcarbamylase deficiency urea cycle metabolism disorder?
- E72.4 — Disorders of ornithine metabolism.
What is the ICD-10 code for other specified urea cycle metabolism disorder?
- E72.29 — Other disorders of urea cycle metabolism.
Is E72.20 billable?
- Yes. E72.20 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E72.20 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E72.20 as a principal diagnosis.
Is E72.20 a CC or MCC?
- E72.20 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.