ICD-10-CM 2027
ICD-10 code for susceptibility to disease
From the official ICD-10-CM alphabetic index entry “Susceptibility to disease, genetic”. Page updated September 29, 2026.
About coding susceptibility to disease
The ICD-10-CM code for susceptibility to disease is Z15.89 (Genetic susceptibility to other disease). The official index lists 9 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on Z15.89.
Within Z15.8, choose Z15.89 (other disease) only when documentation doesn't support a more specific option: multiple endocrine neoplasia [MEN] (Z15.81).
Use an additional code, if applicable, for any associated family history of the disease (Z80-Z84).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific susceptibility to disease codes (official index)
- hereditary nonpolyposis colorectal cancer QA1.71 — Lynch syndrome
- malignant neoplasm Z15.09 — Genetic susceptibility to other malignant neoplasm
- breast Z15.01 — Genetic susceptibility to malignant neoplasm of breast
- endometrium Z15.04 — Genetic susceptibility to malignant neoplasm of endometrium
- fallopian tube (s) Z15.05 — Genetic susceptibility to malignant neoplasm of fallopian tube(s)
- ovary Z15.02 — Genetic susceptibility to malignant neoplasm of ovary
- prostate Z15.03 — Genetic susceptibility to malignant neoplasm of prostate
- specified NEC Z15.09 — Genetic susceptibility to other malignant neoplasm
- multiple endocrine neoplasia Z15.81 — Genetic susceptibility to multiple endocrine neoplasia [MEN]
Common questions about susceptibility to disease ICD-10 codes
What is the ICD-10 code for susceptibility to disease?
- Z15.89 — Genetic susceptibility to other disease. More specific codes apply when the documentation supports them: QA1.71, Z15.09, Z15.01, Z15.04 and others below.
What is the ICD-10 code for hereditary nonpolyposis colorectal cancer susceptibility to disease?
- QA1.71 — Lynch syndrome.
What is the ICD-10 code for malignant neoplasm susceptibility to disease?
- Z15.09 — Genetic susceptibility to other malignant neoplasm.
What is the ICD-10 code for multiple endocrine neoplasia susceptibility to disease?
- Z15.81 — Genetic susceptibility to multiple endocrine neoplasia [MEN].
Is Z15.89 billable?
- Yes. Z15.89 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z15.89 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z15.89 a CC or MCC?
- No. Z15.89 is neither a CC nor an MCC under MS-DRG v44.0.