ICD-10-CM 2027
ICD-10 code for secondary systemic amyloidosis
From the official ICD-10-CM alphabetic index entry “Amyloidosis (generalized) (primary) › secondary systemic”. Page updated September 29, 2026.
About coding secondary systemic amyloidosis
The ICD-10-CM code for secondary systemic amyloidosis is E85.3 (Secondary systemic amyloidosis).
Within E85 (amyloidosis), E85.3 is specifically for secondary systemic amyloidosis. Related codes cover Non-neuropathic heredofamilial amyloidosis (E85.0), neuropathic heredofamilial amyloidosis (E85.1), heredofamilial amyloidosis, unspecified (E85.2), Organ-limited amyloidosis (E85.4), other amyloidosis (E85.8) and unspecified (E85.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 545 (Connective Tissue Disorders with MCC, relative weight 2.3892), DRG 546 (Connective Tissue Disorders with CC, relative weight 1.1745) and DRG 547 (Connective Tissue Disorders without CC/MCC, relative weight 0.7526), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about secondary systemic amyloidosis ICD-10 codes
What is the ICD-10 code for secondary systemic amyloidosis?
- E85.3 — Secondary systemic amyloidosis.
Is E85.3 billable?
- Yes. E85.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E85.3 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E85.3 as a principal diagnosis.
Is E85.3 a CC or MCC?
- E85.3 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.