ICD-10-CM 2027
ICD-10 code for resistant organism infection drug
From the official ICD-10-CM alphabetic index entry “Drug › resistant organism infection”. Page updated September 29, 2026.
About coding resistant organism infection drug
The ICD-10-CM code for resistant organism infection drug is Z16.30 (Resistance to unspecified antimicrobial drugs).
Within Z16.3, choose Z16.30 (unspecified antimicrobial drugs) only when documentation doesn't support a more specific option: antiparasitic drug(s) (Z16.31), antifungal drug(s) (Z16.32), antiviral drug(s) (Z16.33), antimycobacterial drug(s) (Z16.34), multiple antimicrobial drugs (Z16.35) and other specified antimicrobial drug (Z16.39).
Code first: the infection.
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
Common questions about resistant organism infection drug ICD-10 codes
What is the ICD-10 code for resistant organism infection drug?
- Z16.30 — Resistance to unspecified antimicrobial drugs.
Is Z16.30 billable?
- Yes. Z16.30 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z16.30 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z16.30 a CC or MCC?
- No. Z16.30 is neither a CC nor an MCC under MS-DRG v44.0.