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ICD-10-CM 2027

ICD-10 code for Pyonephritis

N12

Tubulo-interstitial nephritis, not specified as acute or chronic

✓ Billable / specificCC — complication/comorbidity

From the official ICD-10-CM alphabetic index entry “Pyonephritis”. Page updated September 29, 2026.

About coding Pyonephritis

The ICD-10-CM code for Pyonephritis is N12 (Tubulo-interstitial nephritis, not specified as acute or chronic).

Don't report N12 together with the conditions in its Excludes1 note: calculous pyelonephritis (N20.9).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 689 (Kidney and Urinary Tract Infections with MCC, relative weight 1.1415), DRG 690 (Kidney and Urinary Tract Infections without MCC, relative weight 0.801), DRG 791 (Prematurity with Major Problems, relative weight 4.1075) and DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), in MDC 11 (Diseases and Disorders of the Kidney and Urinary Tract) and MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Don't confuse with (Excludes1 for N12)

  • calculous pyelonephritis (N20.9)

Common questions about Pyonephritis ICD-10 codes

What is the ICD-10 code for Pyonephritis?

N12 — Tubulo-interstitial nephritis, not specified as acute or chronic.

Is N12 billable?

Yes. N12 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can N12 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict N12 as a principal diagnosis.

Is N12 a CC or MCC?

N12 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.