ICD-10-CM 2027
ICD-10 code for Psychophysiologic dysfunction
Unspecified behavioral syndromes associated with physiological disturbances and physical factors
From the official ICD-10-CM alphabetic index entry “Dysfunction › psychophysiologic”. Page updated September 29, 2026.
About coding Psychophysiologic dysfunction
The ICD-10-CM code for Psychophysiologic dysfunction is F59 (Unspecified behavioral syndromes associated with physiological disturbances and physical factors).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 887 (Other Mental Disorder Diagnoses, relative weight 1.1139), in MDC 19 (Mental Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Common questions about Psychophysiologic dysfunction ICD-10 codes
What is the ICD-10 code for Psychophysiologic dysfunction?
- F59 — Unspecified behavioral syndromes associated with physiological disturbances and physical factors.
Is F59 billable?
- Yes. F59 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can F59 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict F59 as a principal diagnosis.
Is F59 a CC or MCC?
- No. F59 is neither a CC nor an MCC under MS-DRG v44.0.