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Dx

ICD-10-CM 2027

ICD-10 code for Paraneoplastic neuropathy

D49.9

Neoplasm of unspecified behavior of unspecified site

✓ Billable / specific

From the official ICD-10-CM alphabetic index entry “Neuropathy, neuropathic › paraneoplastic (sensorial) (Denny Brown) (see also, Neoplasm, by site, if known)”. Page updated September 29, 2026.

About coding Paraneoplastic neuropathy

The ICD-10-CM code for Paraneoplastic neuropathy is D49.9 (Neoplasm of unspecified behavior of unspecified site).

Within D49, choose D49.9 (unspecified site) only when documentation doesn't support a more specific option: digestive system (D49.0), respiratory system (D49.1), bone, soft tissue, and skin (D49.2), breast (D49.3), bladder (D49.4), other genitourinary organs (D49.5), brain (D49.6), endocrine glands and other parts of nervous system (D49.7) and 1 more.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 826 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with MCC, relative weight 4.7581), DRG 827 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures with CC, relative weight 2.3896), DRG 828 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures without CC/MCC, relative weight 1.6955), DRG 829 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures with CC/MCC, relative weight 3.1281), DRG 830 (Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Other Procedures without CC/MCC, relative weight 1.4859), DRG 843 (Other Myeloproliferative Disorders or Poorly Differentiated Neoplastic Diagnoses with MCC, relative weight 1.9453) and 2 more, in MDC 17 (Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Common questions about Paraneoplastic neuropathy ICD-10 codes

What is the ICD-10 code for Paraneoplastic neuropathy?

D49.9 — Neoplasm of unspecified behavior of unspecified site.

Is D49.9 billable?

Yes. D49.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D49.9 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D49.9 as a principal diagnosis.

Is D49.9 a CC or MCC?

No. D49.9 is neither a CC nor an MCC under MS-DRG v44.0.