ICD-10-CM 2027
ICD-10 code for pancreatic islet cells hyperplasia
From the official ICD-10-CM alphabetic index entry “Hyperplasia, hyperplastic › pancreatic islet cells”. Page updated September 29, 2026.
About coding pancreatic islet cells hyperplasia
The ICD-10-CM code for pancreatic islet cells hyperplasia is E16.9 (Disorder of pancreatic internal secretion, unspecified). The official index lists 4 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E16.9.
Within E16, choose E16.9 (Disorder of pancreatic internal secretion, unspecified) only when documentation doesn't support a more specific option: drug-induced hypoglycemia without coma (E16.0), other hypoglycemia (E16.1), hypoglycemia, unspecified (E16.2), increased secretion of glucagon (E16.3), increased secretion of gastrin (E16.4), other specified disorders of pancreatic internal secretion (E16.8) and hypoglycemia level (E16.A).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific pancreatic islet cells hyperplasia codes (official index)
Common questions about pancreatic islet cells hyperplasia ICD-10 codes
What is the ICD-10 code for pancreatic islet cells hyperplasia?
- E16.9 — Disorder of pancreatic internal secretion, unspecified. More specific codes apply when the documentation supports them: E16.8, E16.4, E16.3, E16.1.
What is the ICD-10 code for alpha pancreatic islet cells hyperplasia?
- E16.8 — Other specified disorders of pancreatic internal secretion.
What is the ICD-10 code for beta pancreatic islet cells hyperplasia?
- E16.1 — Other hypoglycemia.
Is E16.9 billable?
- Yes. E16.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E16.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E16.9 as a principal diagnosis.
Is E16.9 a CC or MCC?
- No. E16.9 is neither a CC nor an MCC under MS-DRG v44.0.