ICD-10-CM 2027
ICD-10 code for nonautoimmune hemolytic anemia
From the official ICD-10-CM alphabetic index entry “Nonautoimmune hemolytic anemia”. Page updated September 29, 2026.
About coding nonautoimmune hemolytic anemia
The ICD-10-CM code for nonautoimmune hemolytic anemia is D59.4 (Other nonautoimmune hemolytic anemias). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on D59.4.
Within D59, choose D59.4 (Other nonautoimmune hemolytic anemias) only when documentation doesn't support a more specific option: drug-induced autoimmune hemolytic anemia (D59.0), other autoimmune hemolytic anemias (D59.1), drug-induced nonautoimmune hemolytic anemia (D59.2), hemolytic-uremic syndrome (D59.3), paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] (D59.5), hemoglobinuria due to hemolysis from other external causes (D59.6), other acquired hemolytic anemias (D59.8) and unspecified (D59.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 808 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC, relative weight 2.1705), DRG 809 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC, relative weight 1.2262) and DRG 810 (Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC, relative weight 1.075), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific nonautoimmune hemolytic anemia codes (official index)
- drug-induced D59.2 — Drug-induced nonautoimmune hemolytic anemia
Common questions about nonautoimmune hemolytic anemia ICD-10 codes
What is the ICD-10 code for nonautoimmune hemolytic anemia?
- D59.4 — Other nonautoimmune hemolytic anemias. More specific codes apply when the documentation supports them: D59.2.
What is the ICD-10 code for drug-induced nonautoimmune hemolytic anemia?
- D59.2 — Drug-induced nonautoimmune hemolytic anemia.
Is D59.4 billable?
- Yes. D59.4 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D59.4 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D59.4 as a principal diagnosis.
Is D59.4 a CC or MCC?
- D59.4 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.