ICD-10-CM 2027
ICD-10 code for Methylenetetrahydrofolate reductase MTHFR deficiency
Methylenetetrahydrofolate reductase deficiency
From the official ICD-10-CM alphabetic index entry “Deficiency, deficient › methylenetetrahydrofolate reductase (MTHFR)”. Page updated September 29, 2026.
About coding Methylenetetrahydrofolate reductase MTHFR deficiency
The ICD-10-CM code for Methylenetetrahydrofolate reductase MTHFR deficiency is E72.12 (Methylenetetrahydrofolate reductase deficiency).
Within E72.1 (disorders of sulfur-bearing amino-acid metabolism), E72.12 is specifically for Methylenetetrahydrofolate reductase deficiency. Related codes cover unspecified (E72.10), Homocystinuria (E72.11) and other disorders of sulfur-bearing amino-acid metabolism (E72.19).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Methylenetetrahydrofolate reductase MTHFR deficiency ICD-10 codes
What is the ICD-10 code for Methylenetetrahydrofolate reductase MTHFR deficiency?
- E72.12 — Methylenetetrahydrofolate reductase deficiency.
Is E72.12 billable?
- Yes. E72.12 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E72.12 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E72.12 as a principal diagnosis.
Is E72.12 a CC or MCC?
- E72.12 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.