ICD-10-CM 2027
ICD-10 code for LTBL
From the official ICD-10-CM alphabetic index entry “LTBL (leukoencephalopathy with thalamus - brainstem involvement - high lactate)”. Page updated September 29, 2026.
About coding LTBL
The ICD-10-CM code for LTBL is E88.43 (Disorders of mitochondrial tRNA synthetases).
Within E88.4 (mitochondrial metabolism disorders), E88.43 is specifically for disorders of mitochondrial tRNA synthetases. Related codes cover mitochondrial metabolism disorder, unspecified (E88.40), MELAS syndrome (E88.41), MERRF syndrome (E88.42) and other mitochondrial metabolism disorders (E88.49).
Use an additional code for: codes for associated conditions.
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
Common questions about LTBL ICD-10 codes
What is the ICD-10 code for LTBL?
- E88.43 — Disorders of mitochondrial tRNA synthetases.
Is E88.43 billable?
- Yes. E88.43 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E88.43 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E88.43 as a principal diagnosis.
Is E88.43 a CC or MCC?
- E88.43 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.