ICD-10-CM 2027
ICD-10 code for light chain AL amyloidosis
From the official ICD-10-CM alphabetic index entry “Amyloidosis (generalized) (primary) › light chain (AL)”. Page updated September 29, 2026.
About coding light chain AL amyloidosis
The ICD-10-CM code for light chain AL amyloidosis is E85.81 (Light chain (AL) amyloidosis).
Within E85.8 (other amyloidosis), E85.81 is specifically for light chain (AL) amyloidosis. Related codes cover Wild-type transthyretin-related (ATTR) amyloidosis (E85.82) and other amyloidosis (E85.89).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 545 (Connective Tissue Disorders with MCC, relative weight 2.3892), DRG 546 (Connective Tissue Disorders with CC, relative weight 1.1745) and DRG 547 (Connective Tissue Disorders without CC/MCC, relative weight 0.7526), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about light chain AL amyloidosis ICD-10 codes
What is the ICD-10 code for light chain AL amyloidosis?
- E85.81 — Light chain (AL) amyloidosis.
Is E85.81 billable?
- Yes. E85.81 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E85.81 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E85.81 as a principal diagnosis.
Is E85.81 a CC or MCC?
- E85.81 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.