ICD-10-CM 2027
ICD-10 code for leukodystrophy
From the official ICD-10-CM alphabetic index entry “Leukodystrophy”. Page updated September 29, 2026.
About coding leukodystrophy
The ICD-10-CM code for leukodystrophy is G31.80 (Leukodystrophy, unspecified). The official index lists 4 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on G31.80.
Within G31.8, choose G31.80 (Leukodystrophy, unspecified) only when documentation doesn't support a more specific option: Alpers disease (G31.81), Leigh's disease (G31.82), neurocognitive disorder with Lewy bodies (G31.83), mild cognitive impairment of uncertain or unknown etiology (G31.84), Corticobasal degeneration (G31.85), Alexander disease (G31.86), primary progressive apraxia of speech (G31.87) and other specified degenerative diseases of nervous system (G31.89).
Use an additional code, if applicable, for codes G31.0-G31.83, G31.85-G31.9, to identify: dementia with anxiety (F02.84, F02.A4, F02.B4, F02.C4), dementia with behavioral disturbance (F02.81-, F02.A1-, F02.B1-, F02.C1-), dementia with mood disturbance (F02.83, F02.A3, F02.B3, F02.C3), dementia with psychotic disturbance (F02.82, F02.A2, F02.B2, F02.C2), dementia without behavioral disturbance (F02.80, F02.A0, F02.B0, F02.C0) and 1 more.
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific leukodystrophy codes (official index)
- with vanishing white matter disease G11.6 — Leukodystrophy with vanishing white matter disease
- LMNB1-related autosomal dominant G90.B — LMNB1-related autosomal dominant leukodystrophy
- metachromatic E75.25 — Metachromatic leukodystrophy
- pol III-related G11.5 — Hypomyelination - hypogonadotropic hypogonadism - hypodontia
Common questions about leukodystrophy ICD-10 codes
What is the ICD-10 code for leukodystrophy?
- G31.80 — Leukodystrophy, unspecified. More specific codes apply when the documentation supports them: G11.6, G90.B, E75.25, G11.5.
What is the ICD-10 code for lmnb1-related autosomal dominant leukodystrophy?
- G90.B — LMNB1-related autosomal dominant leukodystrophy.
What is the ICD-10 code for metachromatic leukodystrophy?
- E75.25 — Metachromatic leukodystrophy.
What is the ICD-10 code for pol iii-related leukodystrophy?
- G11.5 — Hypomyelination - hypogonadotropic hypogonadism - hypodontia.
Is G31.80 billable?
- Yes. G31.80 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can G31.80 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict G31.80 as a principal diagnosis.
Is G31.80 a CC or MCC?
- No. G31.80 is neither a CC nor an MCC under MS-DRG v44.0.