ICD-10-CM 2027
ICD-10 code for immunoproliferative malignant disease
From the official ICD-10-CM alphabetic index entry “Disease, diseased › immunoproliferative (malignant)”. Page updated September 29, 2026.
About coding immunoproliferative malignant disease
The ICD-10-CM code for immunoproliferative malignant disease is C88.9 (Malignant immunoproliferative disease, unspecified). The official index lists 2 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on C88.9.
Within C88, choose C88.9 (Malignant immunoproliferative disease, unspecified) only when documentation doesn't support a more specific option: Waldenstrom macroglobulinemia (C88.0), heavy chain disease (C88.2), immunoproliferative small intestinal disease (C88.3), extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] (C88.4) and other malignant immunoproliferative diseases (C88.8).
To report this condition, pick the subcode that matches the documentation: C88.90 (not having achieved remission) and C88.91 (in remission).
It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2025 (expanded into subcodes).
More specific immunoproliferative malignant disease codes (official index)
Common questions about immunoproliferative malignant disease ICD-10 codes
What is the ICD-10 code for immunoproliferative malignant disease?
- C88.9 — Malignant immunoproliferative disease, unspecified (a header code; report a more specific subcode). More specific codes apply when the documentation supports them: C88.3, C88.8.
What is the ICD-10 code for small intestinal immunoproliferative malignant disease?
- C88.3 — Immunoproliferative small intestinal disease (header code; choose a more specific subcode).
Is C88.9 billable?
- No. C88.9 is a header code. Report one of its more specific subcodes instead.