ICD-10-CM 2027
ICD-10 code for immune reconstitution syndrome
From the official ICD-10-CM alphabetic index entry “Syndrome › immune reconstitution”. Page updated September 29, 2026.
About coding immune reconstitution syndrome
The ICD-10-CM code for immune reconstitution syndrome is D89.3 (Immune reconstitution syndrome).
Within D89 (other disorders involving the immune mechanism, not elsewhere classified), D89.3 is specifically for immune reconstitution syndrome. Related codes cover Polyclonal hypergammaglobulinemia (D89.0), Cryoglobulinemia (D89.1), hypergammaglobulinemia, unspecified (D89.2), mast cell activation syndrome and related disorders (D89.4), other specified disorders involving the immune mechanism, not elsewhere classified (D89.8) and disorder involving the immune mechanism, unspecified (D89.9).
Use an additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
Common questions about immune reconstitution syndrome ICD-10 codes
What is the ICD-10 code for immune reconstitution syndrome?
- D89.3 — Immune reconstitution syndrome.
Is D89.3 billable?
- Yes. D89.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D89.3 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D89.3 as a principal diagnosis.
Is D89.3 a CC or MCC?
- No. D89.3 is neither a CC nor an MCC under MS-DRG v44.0.