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ICD-10-CM 2027

ICD-10 code for hypogammaglobulinemia

D80.1

Nonfamilial hypogammaglobulinemia

✓ Billable / specificCC — complication/comorbidity

From the official ICD-10-CM alphabetic index entry “Hypogammaglobulinemia”. Page updated September 29, 2026.

About coding hypogammaglobulinemia

The ICD-10-CM code for hypogammaglobulinemia is D80.1 (Nonfamilial hypogammaglobulinemia). The official index lists 3 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D80.1.

Within D80 (immunodeficiency with predominantly antibody defects), D80.1 is specifically for nonfamilial hypogammaglobulinemia. Related codes cover hereditary hypogammaglobulinemia (D80.0), selective deficiency of immunoglobulin A [IgA] (D80.2), selective deficiency of immunoglobulin G [IgG] subclasses (D80.3), selective deficiency of immunoglobulin M [IgM] (D80.4), immunodeficiency with increased immunoglobulin M [IgM] (D80.5), antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia (D80.6), transient hypogammaglobulinemia of infancy (D80.7), other immunodeficiencies with predominantly antibody defects (D80.8) and 1 more.

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 814 (Reticuloendothelial and Immunity Disorders with MCC, relative weight 2.0729), DRG 815 (Reticuloendothelial and Immunity Disorders with CC, relative weight 1.0444) and DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC, relative weight 0.7381), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

More specific hypogammaglobulinemia codes (official index)

  • hereditary D80.0 — Hereditary hypogammaglobulinemia
  • nonfamilial D80.1 — Nonfamilial hypogammaglobulinemia
  • transient, of infancy D80.7 — Transient hypogammaglobulinemia of infancy

Common questions about hypogammaglobulinemia ICD-10 codes

What is the ICD-10 code for hypogammaglobulinemia?

D80.1 — Nonfamilial hypogammaglobulinemia. More specific codes apply when the documentation supports them: D80.0, D80.1, D80.7.

What is the ICD-10 code for hereditary hypogammaglobulinemia?

D80.0 — Hereditary hypogammaglobulinemia.

What is the ICD-10 code for nonfamilial hypogammaglobulinemia?

D80.1 — Nonfamilial hypogammaglobulinemia.

Is D80.1 billable?

Yes. D80.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D80.1 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D80.1 as a principal diagnosis.

Is D80.1 a CC or MCC?

D80.1 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.