ICD-10-CM 2027
ICD-10 code for Hypoadrenalism
From the official ICD-10-CM alphabetic index entry “Hypoadrenalism, hypoadrenia”. Page updated September 29, 2026.
About coding Hypoadrenalism
The ICD-10-CM code for Hypoadrenalism is E27.40 (Unspecified adrenocortical insufficiency). The official index lists 2 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E27.40.
Within E27.4, choose E27.40 (Unspecified adrenocortical insufficiency) only when documentation doesn't support a more specific option: other adrenocortical insufficiency (E27.49).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific Hypoadrenalism codes (official index)
Common questions about Hypoadrenalism ICD-10 codes
What is the ICD-10 code for Hypoadrenalism?
- E27.40 — Unspecified adrenocortical insufficiency. More specific codes apply when the documentation supports them: E27.1, A18.7.
What is the ICD-10 code for primary hypoadrenalism?
- E27.1 — Primary adrenocortical insufficiency.
What is the ICD-10 code for tuberculous hypoadrenalism?
- A18.7 — Tuberculosis of adrenal glands.
Is E27.40 billable?
- Yes. E27.40 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E27.40 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E27.40 as a principal diagnosis.
Is E27.40 a CC or MCC?
- E27.40 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.