ICD-10-CM 2027
ICD-10 code for Hyperprolactinemia
From the official ICD-10-CM alphabetic index entry “Hyperprolactinemia”. Page updated September 29, 2026.
About coding Hyperprolactinemia
The ICD-10-CM code for Hyperprolactinemia is E22.1 (Hyperprolactinemia).
Within E22 (hyperfunction of pituitary gland), E22.1 is specifically for Hyperprolactinemia. Related codes cover Acromegaly and pituitary gigantism (E22.0), syndrome of inappropriate secretion of antidiuretic hormone (E22.2), other hyperfunction of pituitary gland (E22.8) and unspecified (E22.9).
Use an additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
Common questions about Hyperprolactinemia ICD-10 codes
What is the ICD-10 code for Hyperprolactinemia?
- E22.1 — Hyperprolactinemia.
Is E22.1 billable?
- Yes. E22.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E22.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E22.1 as a principal diagnosis.
Is E22.1 a CC or MCC?
- E22.1 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.