Skip to content
Dx

ICD-10-CM 2027

ICD-10 code for Hyperpituitarism

E22.9

Hyperfunction of pituitary gland, unspecified

✓ Billable / specificCC — complication/comorbidity

From the official ICD-10-CM alphabetic index entry “Hyperpituitarism”. Page updated September 29, 2026.

About coding Hyperpituitarism

The ICD-10-CM code for Hyperpituitarism is E22.9 (Hyperfunction of pituitary gland, unspecified).

Within E22, choose E22.9 (unspecified) only when documentation doesn't support a more specific option: Acromegaly and pituitary gigantism (E22.0), Hyperprolactinemia (E22.1), syndrome of inappropriate secretion of antidiuretic hormone (E22.2) and other hyperfunction of pituitary gland (E22.8).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Common questions about Hyperpituitarism ICD-10 codes

What is the ICD-10 code for Hyperpituitarism?

E22.9 — Hyperfunction of pituitary gland, unspecified.

Is E22.9 billable?

Yes. E22.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E22.9 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E22.9 as a principal diagnosis.

Is E22.9 a CC or MCC?

E22.9 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.