ICD-10-CM 2027
ICD-10 code for hyperlipidemia
Confirmed by the official ICD-10-CM index entry “hyperlipemia, hyperlipidemia”. Page updated September 29, 2026.
About coding hyperlipidemia
The ICD-10-CM code for hyperlipidemia is E78.5 (Hyperlipidemia, unspecified). The official index lists 17 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E78.5.
It is also searched as high cholesterol, HLD, dyslipidemia.
Within E78, choose E78.5 (Hyperlipidemia, unspecified) only when documentation doesn't support a more specific option: pure hypercholesterolemia (E78.0), pure hyperglyceridemia (E78.1), mixed hyperlipidemia (E78.2), Hyperchylomicronemia (E78.3), other hyperlipidemia (E78.4), lipoprotein deficiency (E78.6), disorders of bile acid and cholesterol metabolism (E78.7), other disorders of lipoprotein metabolism (E78.8) and 1 more.
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Related Hyperlipidemia codes
- E78.00 Pure hypercholesterolemia, unspecified
- E78.010 Homozygous familial hypercholesterolemia [HoFH]
- E78.011 Heterozygous familial hypercholesterolemia [HeFH]
- E78.019 Familial hypercholesterolemia, unspecified
- E78.1 Pure hyperglyceridemia
- E78.2 Mixed hyperlipidemia
- E78.3 Hyperchylomicronemia
- E78.41 Elevated Lipoprotein(a)
- E78.49 Other hyperlipidemia
- E78.6 Lipoprotein deficiency
- E78.70 Disorder of bile acid and cholesterol metabolism, unspecified
- E78.71 Barth syndrome
- E78.72 Smith-Lemli-Opitz syndrome
- E78.79 Other disorders of bile acid and cholesterol metabolism
- E78.81 Lipoid dermatoarthritis
- E78.89 Other lipoprotein metabolism disorders
- E78.9 Disorder of lipoprotein metabolism, unspecified
Common questions about hyperlipidemia ICD-10 codes
What is the ICD-10 code for hyperlipidemia?
- E78.5 — Hyperlipidemia, unspecified. More specific codes apply when the documentation supports them: E78.00, E78.010, E78.011, E78.019 and others below.
What is the ICD-10 code for pure hypercholesterolemia, unspecified?
- E78.00 — Pure hypercholesterolemia, unspecified.
What is the ICD-10 code for homozygous familial hypercholesterolemia [hofh]?
- E78.010 — Homozygous familial hypercholesterolemia [HoFH].
What is the ICD-10 code for heterozygous familial hypercholesterolemia [hefh]?
- E78.011 — Heterozygous familial hypercholesterolemia [HeFH].
What is the ICD-10 code for familial hypercholesterolemia, unspecified?
- E78.019 — Familial hypercholesterolemia, unspecified.
What is the ICD-10 code for pure hyperglyceridemia?
- E78.1 — Pure hyperglyceridemia.
What is the ICD-10 code for mixed hyperlipidemia?
- E78.2 — Mixed hyperlipidemia.
Is E78.5 billable?
- Yes. E78.5 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E78.5 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E78.5 as a principal diagnosis.
Is E78.5 a CC or MCC?
- No. E78.5 is neither a CC nor an MCC under MS-DRG v44.0.