ICD-10-CM 2027
ICD-10 code for hypercholesterolemia
From the official ICD-10-CM alphabetic index entry “Hypercholesterolemia (essential) (primary) (pure)”. Page updated September 29, 2026.
About coding hypercholesterolemia
The ICD-10-CM code for hypercholesterolemia is E78.00 (Pure hypercholesterolemia, unspecified). The official index lists 6 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E78.00.
Within E78.0, choose E78.00 (unspecified) only when documentation doesn't support a more specific option: familial hypercholesterolemia (E78.01).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific hypercholesterolemia codes (official index)
- with hyperglyceridemia, endogenous E78.2 — Mixed hyperlipidemia
- dietary counseling and surveillance Z71.3 — Dietary counseling and surveillance
- familial E78.019 — Familial hypercholesterolemia, unspecified
- homozygous [HoFH] E78.010 — Homozygous familial hypercholesterolemia [HoFH]
- heterozygous [HeFH] E78.011 — Heterozygous familial hypercholesterolemia [HeFH]
- hereditary E78.019 — Familial hypercholesterolemia, unspecified
Common questions about hypercholesterolemia ICD-10 codes
What is the ICD-10 code for hypercholesterolemia?
- E78.00 — Pure hypercholesterolemia, unspecified. More specific codes apply when the documentation supports them: E78.2, Z71.3, E78.019, E78.010 and others below.
What is the ICD-10 code for dietary counseling and surveillance hypercholesterolemia?
- Z71.3 — Dietary counseling and surveillance.
What is the ICD-10 code for familial hypercholesterolemia?
- E78.019 — Familial hypercholesterolemia, unspecified.
What is the ICD-10 code for hereditary hypercholesterolemia?
- E78.019 — Familial hypercholesterolemia, unspecified.
Is E78.00 billable?
- Yes. E78.00 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E78.00 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E78.00 as a principal diagnosis.
Is E78.00 a CC or MCC?
- No. E78.00 is neither a CC nor an MCC under MS-DRG v44.0.