ICD-10-CM 2027
ICD-10 code for hormone replacement long-term drug therapy
From the official ICD-10-CM alphabetic index entry “Long-term (current) (prophylactic) drug therapy (use of) › hormone replacement”. Page updated September 29, 2026.
About coding hormone replacement long-term drug therapy
The ICD-10-CM code for hormone replacement long-term drug therapy is Z79.890 (Hormone replacement therapy).
Within Z79.89 (other long term (current) drug therapy), Z79.890 is specifically for hormone replacement therapy. Related codes cover long term (current) use of opiate analgesic (Z79.891) and other long term (current) drug therapy (Z79.899).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about hormone replacement long-term drug therapy ICD-10 codes
What is the ICD-10 code for hormone replacement long-term drug therapy?
- Z79.890 — Hormone replacement therapy.
Is Z79.890 billable?
- Yes. Z79.890 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z79.890 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z79.890 a CC or MCC?
- No. Z79.890 is neither a CC nor an MCC under MS-DRG v44.0.