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ICD-10-CM 2027

ICD-10 code for Hepatosplenomegaly

R16.2

Hepatomegaly with splenomegaly, not elsewhere classified

✓ Billable / specific

From the official ICD-10-CM alphabetic index entry “Hepatosplenomegaly”. Page updated September 29, 2026.

About coding Hepatosplenomegaly

The ICD-10-CM code for Hepatosplenomegaly is R16.2 (Hepatomegaly with splenomegaly, not elsewhere classified). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on R16.2.

Within R16 (Hepatomegaly and splenomegaly, not elsewhere classified), R16.2 is specifically for Hepatomegaly with splenomegaly, not elsewhere classified. Related codes cover Hepatomegaly, not elsewhere classified (R16.0) and splenomegaly, not elsewhere classified (R16.1).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 441 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with MCC, relative weight 1.8219), DRG 442 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with CC, relative weight 0.9602) and DRG 443 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis without CC/MCC, relative weight 0.6885), in MDC 07 (Diseases and Disorders of the Hepatobiliary System and Pancreas), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

More specific Hepatosplenomegaly codes (official index)

  • hyperlipemic (Bürger-Grütz type) E78.3 — Hyperchylomicronemia

Common questions about Hepatosplenomegaly ICD-10 codes

What is the ICD-10 code for Hepatosplenomegaly?

R16.2 — Hepatomegaly with splenomegaly, not elsewhere classified. More specific codes apply when the documentation supports them: E78.3.

What is the ICD-10 code for hyperlipemic hepatosplenomegaly?

E78.3 — Hyperchylomicronemia.

Is R16.2 billable?

Yes. R16.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can R16.2 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict R16.2 as a principal diagnosis.

Is R16.2 a CC or MCC?

No. R16.2 is neither a CC nor an MCC under MS-DRG v44.0.