ICD-10-CM 2027
ICD-10 code for globulin abnormal
From the official ICD-10-CM alphabetic index entry “Abnormal, abnormality, abnormalities › globulin”. Page updated September 29, 2026.
About coding globulin abnormal
The ICD-10-CM code for globulin abnormal is R77.1 (Abnormality of globulin). The official index lists 2 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on R77.1.
Within R77 (other abnormalities of plasma proteins), R77.1 is specifically for abnormality of globulin. Related codes cover abnormality of albumin (R77.0), abnormality of alphafetoprotein (R77.2), other specified abnormalities of plasma proteins (R77.8) and abnormality of plasma protein, unspecified (R77.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 947 (Signs and Symptoms with MCC, relative weight 1.261) and DRG 948 (Signs and Symptoms without MCC, relative weight 0.7835), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific globulin abnormal codes (official index)
Common questions about globulin abnormal ICD-10 codes
What is the ICD-10 code for globulin abnormal?
- R77.1 — Abnormality of globulin. More specific codes apply when the documentation supports them: E27.8, E07.89.
What is the ICD-10 code for cortisol-binding globulin abnormal?
- E27.8 — Other specified disorders of adrenal gland.
What is the ICD-10 code for thyroid-binding globulin abnormal?
- E07.89 — Other specified disorders of thyroid.
Is R77.1 billable?
- Yes. R77.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can R77.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict R77.1 as a principal diagnosis.
Is R77.1 a CC or MCC?
- No. R77.1 is neither a CC nor an MCC under MS-DRG v44.0.