ICD-10-CM 2027
ICD-10 code for general syphilis
From the official ICD-10-CM alphabetic index entry “Syphilis, syphilitic (acquired) › general”. Page updated September 29, 2026.
About coding general syphilis
The ICD-10-CM code for general syphilis is A53.9 (Syphilis, unspecified). The official index lists 2 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on A53.9.
Within A53, choose A53.9 (Syphilis, unspecified) only when documentation doesn't support a more specific option: latent syphilis, unspecified as early or late (A53.0).
Don't report A53.9 together with the conditions in its Excludes1 note: syphilis NOS under two years of age (A50.2).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific general syphilis codes (official index)
Don't confuse with (Excludes1 for A53.9)
- syphilis NOS under two years of age (A50.2)
Common questions about general syphilis ICD-10 codes
What is the ICD-10 code for general syphilis?
- A53.9 — Syphilis, unspecified. More specific codes apply when the documentation supports them: A52.17, A50.45.
What is the ICD-10 code for paralysis general syphilis?
- A52.17 — General paresis.
Is A53.9 billable?
- Yes. A53.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can A53.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict A53.9 as a principal diagnosis.
Is A53.9 a CC or MCC?
- No. A53.9 is neither a CC nor an MCC under MS-DRG v44.0.