ICD-10-CM 2027
ICD-10 code for fructose metabolism disorder
From the official ICD-10-CM alphabetic index entry “Disorder (of) › fructose metabolism”. Page updated September 29, 2026.
About coding fructose metabolism disorder
The ICD-10-CM code for fructose metabolism disorder is E74.10 (Disorder of fructose metabolism, unspecified). The official index lists 5 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E74.10.
Within E74.1, choose E74.10 (Disorder of fructose metabolism, unspecified) only when documentation doesn't support a more specific option: essential fructosuria (E74.11), hereditary fructose intolerance (E74.12) and other disorders of fructose metabolism (E74.19).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 391 (Esophagitis, Gastroenteritis and Miscellaneous Digestive Disorders with MCC, relative weight 1.2392) and DRG 392 (Esophagitis, Gastroenteritis and Miscellaneous Digestive Disorders without MCC, relative weight 0.7645), in MDC 06 (Diseases and Disorders of the Digestive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific fructose metabolism disorder codes (official index)
- essential fructosuria E74.11 — Essential fructosuria
- fructokinase deficiency E74.11 — Essential fructosuria
- fructose-1, 6-diphosphatase deficiency E74.19 — Other disorders of fructose metabolism
- hereditary fructose intolerance E74.12 — Hereditary fructose intolerance
- other specified E74.19 — Other disorders of fructose metabolism
Common questions about fructose metabolism disorder ICD-10 codes
What is the ICD-10 code for fructose metabolism disorder?
- E74.10 — Disorder of fructose metabolism, unspecified. More specific codes apply when the documentation supports them: E74.11, E74.11, E74.19, E74.12 and others below.
What is the ICD-10 code for essential fructosuria fructose metabolism disorder?
- E74.11 — Essential fructosuria.
What is the ICD-10 code for fructokinase deficiency fructose metabolism disorder?
- E74.11 — Essential fructosuria.
What is the ICD-10 code for hereditary fructose intolerance fructose metabolism disorder?
- E74.12 — Hereditary fructose intolerance.
What is the ICD-10 code for other specified fructose metabolism disorder?
- E74.19 — Other disorders of fructose metabolism.
Is E74.10 billable?
- Yes. E74.10 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E74.10 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E74.10 as a principal diagnosis.
Is E74.10 a CC or MCC?
- No. E74.10 is neither a CC nor an MCC under MS-DRG v44.0.