ICD-10-CM 2027
ICD-10 code for Fragility of erythrocytes decrease
From the official ICD-10-CM alphabetic index entry “Decrease (d) › fragility of erythrocytes”. Page updated September 29, 2026.
About coding Fragility of erythrocytes decrease
The ICD-10-CM code for Fragility of erythrocytes decrease is D58.8 (Other specified hereditary hemolytic anemias).
Within D58, choose D58.8 (Other specified hereditary hemolytic anemias) only when documentation doesn't support a more specific option: hereditary spherocytosis (D58.0), hereditary elliptocytosis (D58.1), other hemoglobinopathies (D58.2) and hereditary hemolytic anemia, unspecified (D58.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Fragility of erythrocytes decrease ICD-10 codes
What is the ICD-10 code for Fragility of erythrocytes decrease?
- D58.8 — Other specified hereditary hemolytic anemias.
Is D58.8 billable?
- Yes. D58.8 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D58.8 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D58.8 as a principal diagnosis.
Is D58.8 a CC or MCC?
- D58.8 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.