ICD-10 code for estrogen decrease

The ICD-10-CM code for estrogen decrease is E28.39 (Other primary ovarian failure). The official index lists 3 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E28.39.

Within E28.3, choose E28.39 (Other primary ovarian failure) only when documentation doesn't support a more specific option: premature menopause (E28.31).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 742 (Uterine and Adnexa Procedures for Non-Malignancy with CC/MCC, relative weight 1.8456), DRG 743 (Uterine and Adnexa Procedures for Non-Malignancy without CC/MCC, relative weight 1.2974), DRG 760 (Menstrual and Other Female Reproductive System Disorders with CC/MCC, relative weight 1.0129) and DRG 761 (Menstrual and Other Female Reproductive System Disorders without CC/MCC, relative weight 0.7041), in MDC 13 (Diseases and Disorders of the Female Reproductive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.