ICD-10-CM 2027
ICD-10 code for Endogenous depression
Major depressive disorder, recurrent severe without psychotic features
From the official ICD-10-CM alphabetic index entry “Depression (acute) (mental) › endogenous (without psychotic symptoms)”. Page updated September 29, 2026.
About coding Endogenous depression
The ICD-10-CM code for Endogenous depression is F33.2 (Major depressive disorder, recurrent severe without psychotic features). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on F33.2.
Within F33, choose F33.2 (severe without psychotic features) only when documentation doesn't support a more specific option: mild (F33.0), moderate (F33.1), severe with psychotic symptoms (F33.3), in remission (F33.4), other recurrent depressive disorders (F33.8) and unspecified (F33.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 885 (Psychoses, relative weight 1.3901), in MDC 19 (Mental Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific Endogenous depression codes (official index)
- with psychotic symptoms F33.3 — Major depressive disorder, recurrent, severe with psychotic symptoms
Common questions about Endogenous depression ICD-10 codes
What is the ICD-10 code for Endogenous depression?
- F33.2 — Major depressive disorder, recurrent severe without psychotic features. More specific codes apply when the documentation supports them: F33.3.
Is F33.2 billable?
- Yes. F33.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can F33.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict F33.2 as a principal diagnosis.
Is F33.2 a CC or MCC?
- F33.2 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.