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Dx

ICD-10-CM 2027

ICD-10 code for dependence

F19.20

Other psychoactive substance dependence, uncomplicated

✓ Billable / specificCC — complication/comorbidity

From the official ICD-10-CM alphabetic index entry “Dependence (on) (syndrome)”. Page updated September 29, 2026.

About coding dependence

The ICD-10-CM code for dependence is F19.20 (Other psychoactive substance dependence, uncomplicated). The official index lists 201+ more specific codes, so check the documentation for details such as type, cause, site or severity before settling on F19.20.

Within F19.2 (other psychoactive substance dependence), F19.20 is specifically for other psychoactive substance dependence, uncomplicated. Related codes cover in remission (F19.21), with intoxication (F19.22), with withdrawal (F19.23), with psychoactive substance-induced mood disorder (F19.24), with psychoactive substance-induced psychotic disorder (F19.25), with psychoactive substance-induced persisting amnestic disorder (F19.26), with psychoactive substance-induced persisting dementia (F19.27), with other psychoactive substance-induced disorders (F19.28) and 1 more.

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 894 (Alcohol, Drug Abuse or Dependence, Left AMA, relative weight 0.6275), DRG 895 (Alcohol, Drug Abuse or Dependence with Rehabilitation Therapy, relative weight 1.4266), DRG 896 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy with MCC, relative weight 1.6617) and DRG 897 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy without MCC, relative weight 0.8584), in MDC 20 (Alcohol/Drug Use and Alcohol/Drug Induced Organic Mental Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

More specific dependence codes (official index)

  • with remission F19.21 — Other psychoactive substance dependence, in remission
  • alcohol (ethyl) (methyl) (without remission) F10.20 — Alcohol dependence, uncomplicated
  • with
  • amnestic disorder, persisting F10.26 — Alcohol dependence with alcohol-induced persisting amnestic disorder
  • anxiety disorder F10.280 — Alcohol dependence with alcohol-induced anxiety disorder
  • dementia, persisting F10.27 — Alcohol dependence with alcohol-induced persisting dementia
  • intoxication F10.229 — Alcohol dependence with intoxication, unspecified
  • with delirium F10.221 — Alcohol dependence with intoxication delirium
  • uncomplicated F10.220 — Alcohol dependence with intoxication, uncomplicated
  • mood disorder F10.24 — Alcohol dependence with alcohol-induced mood disorder
  • psychotic disorder F10.259 — Alcohol dependence with alcohol-induced psychotic disorder, unspecified
  • with
  • delusions F10.250 — Alcohol dependence with alcohol-induced psychotic disorder with delusions
  • hallucinations F10.251 — Alcohol dependence with alcohol-induced psychotic disorder with hallucinations
  • remission F10.21 — Alcohol dependence, in remission
  • sexual dysfunction F10.281 — Alcohol dependence with alcohol-induced sexual dysfunction
  • sleep disorder F10.282 — Alcohol dependence with alcohol-induced sleep disorder
  • specified disorder NEC F10.288 — Alcohol dependence with other alcohol-induced disorder
  • withdrawal F10.239 — Alcohol dependence with withdrawal, unspecified
  • with
  • delirium F10.231 — Alcohol dependence with withdrawal delirium
  • perceptual disturbance F10.232 — Alcohol dependence with withdrawal with perceptual disturbance
  • uncomplicated F10.230 — Alcohol dependence with withdrawal, uncomplicated
  • counseling and surveillance Z71.41 — Alcohol abuse counseling and surveillance of alcoholic
  • in remission F10.21 — Alcohol dependence, in remission
  • amobarbital
  • amphetamine (s) (type)
  • amytal (sodium)
  • analgesic NEC F55.8 — Abuse of other non-psychoactive substances
  • anesthetic (agent) (gas) (general) (local) NEC
  • anxiolytic NEC
  • barbital (s)
  • barbiturate (s) (compounds) (drugs classifiable to T42)
  • benzedrine
  • bhang
  • bromide (s) NEC
  • caffeine
  • cannabis (sativa) (indica) (resin) (derivatives) (type)
  • chloral (betaine) (hydrate)
  • chlordiazepoxide
  • coca (leaf) (derivatives)
  • cocaine
  • codeine
  • combinations of drugs F19.20 — Other psychoactive substance dependence, uncomplicated
  • dagga
  • demerol
  • dexamphetamine
  • dexedrine
  • dextromethorphan
  • dextromoramide
  • dextro-nor-pseudo-ephedrine
  • dextrorphan
  • diazepam
  • dilaudid
  • D-lysergic acid diethylamide
  • drug NEC F19.20 — Other psychoactive substance dependence, uncomplicated
  • with sleep disorder F19.282 — Other psychoactive substance dependence with psychoactive substance-induced sleep disorder
  • cannabis F12.20 — Cannabis dependence, uncomplicated
  • with
  • anxiety disorder F12.280 — Cannabis dependence with cannabis-induced anxiety disorder
  • intoxication F12.229 — Cannabis dependence with intoxication, unspecified
  • with
  • delirium F12.221 — Cannabis dependence with intoxication delirium
  • perceptual disturbance F12.222 — Cannabis dependence with intoxication with perceptual disturbance
  • uncomplicated F12.220 — Cannabis dependence with intoxication, uncomplicated
  • other specified disorder F12.288 — Cannabis dependence with other cannabis-induced disorder
  • psychosis F12.259 — Cannabis dependence with psychotic disorder, unspecified
  • delusions F12.250 — Cannabis dependence with psychotic disorder with delusions
  • hallucinations F12.251 — Cannabis dependence with psychotic disorder with hallucinations
  • unspecified disorder F12.29 — Cannabis dependence with unspecified cannabis-induced disorder
  • withdrawal F12.23 — Cannabis dependence with withdrawal
  • in remission F12.21 — Cannabis dependence, in remission
  • cocaine F14.20 — Cocaine dependence, uncomplicated
  • with
  • anxiety disorder F14.280 — Cocaine dependence with cocaine-induced anxiety disorder
  • intoxication F14.229 — Cocaine dependence with intoxication, unspecified
  • with
  • delirium F14.221 — Cocaine dependence with intoxication delirium
  • perceptual disturbance F14.222 — Cocaine dependence with intoxication with perceptual disturbance
  • uncomplicated F14.220 — Cocaine dependence with intoxication, uncomplicated
  • mood disorder F14.24 — Cocaine dependence with cocaine-induced mood disorder
  • other specified disorder F14.288 — Cocaine dependence with other cocaine-induced disorder
  • psychosis F14.259 — Cocaine dependence with cocaine-induced psychotic disorder, unspecified
  • delusions F14.250 — Cocaine dependence with cocaine-induced psychotic disorder with delusions
  • hallucinations F14.251 — Cocaine dependence with cocaine-induced psychotic disorder with hallucinations
  • sexual dysfunction F14.281 — Cocaine dependence with cocaine-induced sexual dysfunction
  • sleep disorder F14.282 — Cocaine dependence with cocaine-induced sleep disorder
  • unspecified disorder F14.29 — Cocaine dependence with unspecified cocaine-induced disorder
  • withdrawal F14.23 — Cocaine dependence with withdrawal
  • in remission F14.21 — Cocaine dependence, in remission
  • withdrawal symptoms in newborn P96.1 — Neonatal withdrawal symptoms from maternal use of drugs of addiction
  • counseling and surveillance Z71.51 — Drug abuse counseling and surveillance of drug abuser
  • hallucinogen F16.20 — Hallucinogen dependence, uncomplicated
  • with
  • anxiety disorder F16.280 — Hallucinogen dependence with hallucinogen-induced anxiety disorder
  • flashbacks F16.283 — Hallucinogen dependence with hallucinogen persisting perception disorder (flashbacks)
  • intoxication F16.229 — Hallucinogen dependence with intoxication, unspecified
  • with delirium F16.221 — Hallucinogen dependence with intoxication with delirium
  • uncomplicated F16.220 — Hallucinogen dependence with intoxication, uncomplicated
  • mood disorder F16.24 — Hallucinogen dependence with hallucinogen-induced mood disorder
  • other specified disorder F16.288 — Hallucinogen dependence with other hallucinogen-induced disorder
  • perception disorder, persisting F16.283 — Hallucinogen dependence with hallucinogen persisting perception disorder (flashbacks)
  • psychosis F16.259 — Hallucinogen dependence with hallucinogen-induced psychotic disorder, unspecified
  • delusions F16.250 — Hallucinogen dependence with hallucinogen-induced psychotic disorder with delusions
  • hallucinations F16.251 — Hallucinogen dependence with hallucinogen-induced psychotic disorder with hallucinations
  • unspecified disorder F16.29 — Hallucinogen dependence with unspecified hallucinogen-induced disorder
  • in remission F16.21 — Hallucinogen dependence, in remission
  • in remission F19.21 — Other psychoactive substance dependence, in remission
  • inhalant F18.20 — Inhalant dependence, uncomplicated
  • with
  • anxiety disorder F18.280 — Inhalant dependence with inhalant-induced anxiety disorder
  • dementia, persisting F18.27 — Inhalant dependence with inhalant-induced dementia
  • intoxication F18.229 — Inhalant dependence with intoxication, unspecified
  • with delirium F18.221 — Inhalant dependence with intoxication delirium
  • uncomplicated F18.220 — Inhalant dependence with intoxication, uncomplicated
  • mood disorder F18.24 — Inhalant dependence with inhalant-induced mood disorder
  • other specified disorder F18.288 — Inhalant dependence with other inhalant-induced disorder
  • psychosis F18.259 — Inhalant dependence with inhalant-induced psychotic disorder, unspecified
  • delusions F18.250 — Inhalant dependence with inhalant-induced psychotic disorder with delusions
  • hallucinations F18.251 — Inhalant dependence with inhalant-induced psychotic disorder with hallucinations
  • unspecified disorder F18.29 — Inhalant dependence with unspecified inhalant-induced disorder
  • in remission F18.21 — Inhalant dependence, in remission
  • nicotine F17.200 — Nicotine dependence, unspecified, uncomplicated
  • with disorder F17.209 — Nicotine dependence, unspecified, with unspecified nicotine-induced disorders
  • in remission F17.201 — Nicotine dependence, unspecified, in remission
  • specified disorder NEC F17.208 — Nicotine dependence, unspecified, with other nicotine-induced disorders
  • withdrawal F17.203 — Nicotine dependence unspecified, with withdrawal
  • chewing tobacco F17.220 — Nicotine dependence, chewing tobacco, uncomplicated
  • with disorder F17.229 — Nicotine dependence, chewing tobacco, with unspecified nicotine-induced disorders
  • in remission F17.221 — Nicotine dependence, chewing tobacco, in remission
  • specified disorder NEC F17.228 — Nicotine dependence, chewing tobacco, with other nicotine-induced disorders
  • withdrawal F17.223 — Nicotine dependence, chewing tobacco, with withdrawal
  • cigarettes F17.210 — Nicotine dependence, cigarettes, uncomplicated
  • with disorder F17.219 — Nicotine dependence, cigarettes, with unspecified nicotine-induced disorders
  • in remission F17.211 — Nicotine dependence, cigarettes, in remission
  • specified disorder NEC F17.218 — Nicotine dependence, cigarettes, with other nicotine-induced disorders
  • withdrawal F17.213 — Nicotine dependence, cigarettes, with withdrawal
  • specified product NEC F17.290 — Nicotine dependence, other tobacco product, uncomplicated
  • with disorder F17.299 — Nicotine dependence, other tobacco product, with unspecified nicotine-induced disorders
  • remission F17.291 — Nicotine dependence, other tobacco product, in remission
  • specified disorder NEC F17.298 — Nicotine dependence, other tobacco product, with other nicotine-induced disorders
  • withdrawal F17.293 — Nicotine dependence, other tobacco product, with withdrawal
  • opioid F11.20 — Opioid dependence, uncomplicated
  • with
  • intoxication F11.229 — Opioid dependence with intoxication, unspecified
  • with
  • delirium F11.221 — Opioid dependence with intoxication delirium
  • perceptual disturbance F11.222 — Opioid dependence with intoxication with perceptual disturbance
  • uncomplicated F11.220 — Opioid dependence with intoxication, uncomplicated
  • mood disorder F11.24 — Opioid dependence with opioid-induced mood disorder
  • opioid-associated amnestic syndrome F11.288 — Opioid dependence with other opioid-induced disorder
  • other specified disorder F11.288 — Opioid dependence with other opioid-induced disorder
  • psychosis F11.259 — Opioid dependence with opioid-induced psychotic disorder, unspecified
  • delusions F11.250 — Opioid dependence with opioid-induced psychotic disorder with delusions
  • hallucinations F11.251 — Opioid dependence with opioid-induced psychotic disorder with hallucinations
  • sexual dysfunction F11.281 — Opioid dependence with opioid-induced sexual dysfunction
  • sleep disorder F11.282 — Opioid dependence with opioid-induced sleep disorder
  • unspecified disorder F11.29 — Opioid dependence with unspecified opioid-induced disorder
  • withdrawal F11.23 — Opioid dependence with withdrawal
  • in remission F11.21 — Opioid dependence, in remission
  • psychoactive NEC F19.20 — Other psychoactive substance dependence, uncomplicated
  • with
  • amnestic disorder F19.26 — Other psychoactive substance dependence with psychoactive substance-induced persisting amnestic disorder
  • anxiety disorder F19.280 — Other psychoactive substance dependence with psychoactive substance-induced anxiety disorder
  • dementia F19.27 — Other psychoactive substance dependence with psychoactive substance-induced persisting dementia
  • intoxication F19.229 — Other psychoactive substance dependence with intoxication, unspecified
  • with
  • delirium F19.221 — Other psychoactive substance dependence with intoxication delirium
  • perceptual disturbance F19.222 — Other psychoactive substance dependence with intoxication with perceptual disturbance
  • uncomplicated F19.220 — Other psychoactive substance dependence with intoxication, uncomplicated
  • mood disorder F19.24 — Other psychoactive substance dependence with psychoactive substance-induced mood disorder
  • other specified disorder F19.288 — Other psychoactive substance dependence with other psychoactive substance-induced disorder
  • psychosis F19.259 — Other psychoactive substance dependence with psychoactive substance-induced psychotic disorder, unspecified
  • delusions F19.250 — Other psychoactive substance dependence with psychoactive substance-induced psychotic disorder with delusions
  • hallucinations F19.251 — Other psychoactive substance dependence with psychoactive substance-induced psychotic disorder with hallucinations
  • sexual dysfunction F19.281 — Other psychoactive substance dependence with psychoactive substance-induced sexual dysfunction
  • sleep disorder F19.282 — Other psychoactive substance dependence with psychoactive substance-induced sleep disorder
  • unspecified disorder F19.29 — Other psychoactive substance dependence with unspecified psychoactive substance-induced disorder
  • withdrawal F19.239 — Other psychoactive substance dependence with withdrawal, unspecified
  • with
  • delirium F19.231 — Other psychoactive substance dependence with withdrawal delirium
  • perceptual disturbance F19.232 — Other psychoactive substance dependence with withdrawal with perceptual disturbance
  • uncomplicated F19.230 — Other psychoactive substance dependence with withdrawal, uncomplicated
  • in remission F19.21 — Other psychoactive substance dependence, in remission
  • sedative, hypnotic or anxiolytic F13.20 — Sedative, hypnotic or anxiolytic dependence, uncomplicated
  • with
  • amnestic disorder F13.26 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced persisting amnestic disorder
  • anxiety disorder F13.280 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced anxiety disorder
  • dementia, persisting F13.27 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced persisting dementia
  • intoxication F13.229 — Sedative, hypnotic or anxiolytic dependence with intoxication, unspecified
  • with delirium F13.221 — Sedative, hypnotic or anxiolytic dependence with intoxication delirium
  • uncomplicated F13.220 — Sedative, hypnotic or anxiolytic dependence with intoxication, uncomplicated
  • mood disorder F13.24 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced mood disorder
  • other specified disorder F13.288 — Sedative, hypnotic or anxiolytic dependence with other sedative, hypnotic or anxiolytic-induced disorder
  • psychosis F13.259 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced psychotic disorder, unspecified
  • delusions F13.250 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced psychotic disorder with delusions
  • hallucinations F13.251 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced psychotic disorder with hallucinations
  • sexual dysfunction F13.281 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced sexual dysfunction
  • sleep disorder F13.282 — Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced sleep disorder
  • unspecified disorder F13.29 — Sedative, hypnotic or anxiolytic dependence with unspecified sedative, hypnotic or anxiolytic-induced disorder
  • withdrawal F13.239 — Sedative, hypnotic or anxiolytic dependence with withdrawal, unspecified
  • with
  • delirium F13.231 — Sedative, hypnotic or anxiolytic dependence with withdrawal delirium
  • perceptual disturbance F13.232 — Sedative, hypnotic or anxiolytic dependence with withdrawal with perceptual disturbance
  • uncomplicated F13.230 — Sedative, hypnotic or anxiolytic dependence with withdrawal, uncomplicated
  • in remission F13.21 — Sedative, hypnotic or anxiolytic dependence, in remission
  • stimulant NEC F15.20 — Other stimulant dependence, uncomplicated
  • with
  • anxiety disorder F15.280 — Other stimulant dependence with stimulant-induced anxiety disorder
  • intoxication F15.229 — Other stimulant dependence with intoxication, unspecified
  • with
  • delirium F15.221 — Other stimulant dependence with intoxication delirium
  • perceptual disturbance F15.222 — Other stimulant dependence with intoxication with perceptual disturbance
  • uncomplicated F15.220 — Other stimulant dependence with intoxication, uncomplicated
  • mood disorder F15.24 — Other stimulant dependence with stimulant-induced mood disorder
  • other specified disorder F15.288 — Other stimulant dependence with other stimulant-induced disorder
  • psychosis F15.259 — Other stimulant dependence with stimulant-induced psychotic disorder, unspecified
  • delusions F15.250 — Other stimulant dependence with stimulant-induced psychotic disorder with delusions
  • hallucinations F15.251 — Other stimulant dependence with stimulant-induced psychotic disorder with hallucinations
  • sexual dysfunction F15.281 — Other stimulant dependence with stimulant-induced sexual dysfunction
  • sleep disorder F15.282 — Other stimulant dependence with stimulant-induced sleep disorder
  • unspecified disorder F15.29 — Other stimulant dependence with unspecified stimulant-induced disorder
  • withdrawal F15.23 — Other stimulant dependence with withdrawal
  • in remission F15.21 — Other stimulant dependence, in remission
  • ethyl
  • alcohol (without remission) F10.20 — Alcohol dependence, uncomplicated
  • with remission F10.21 — Alcohol dependence, in remission
  • bromide
  • carbamate F19.20 — Other psychoactive substance dependence, uncomplicated
  • chloride F19.20 — Other psychoactive substance dependence, uncomplicated
  • morphine
  • ganja
  • glue (airplane) (sniffing)
  • glutethimide
  • hallucinogenics
  • hashish
  • hemp
  • heroin (salt) (any)
  • hypnotic NEC
  • Indian hemp
  • inhalants
  • khat
  • laudanum
  • LSD (-25) (derivatives)
  • luminal
  • lysergic acid
  • maconha
  • marihuana
  • meprobamate
  • mescaline
  • methadone
  • methamphetamine (s)
  • methaqualone
  • methyl
  • alcohol (without remission) F10.20 — Alcohol dependence, uncomplicated
  • with remission F10.21 — Alcohol dependence, in remission
  • bromide
  • morphine
  • phenidate
  • sulfonal
  • morphine (sulfate) (sulfite) (type)
  • narcotic (drug) NEC
  • nembutal
  • neraval
  • neravan
  • neurobarb
  • nicotine
  • nitrous oxide F19.20 — Other psychoactive substance dependence, uncomplicated
  • nonbarbiturate sedatives and tranquilizers with similar effect
  • on
  • artificial heart (fully implantable) (mechanical) Z95.812 — Presence of fully implantable artificial heart
  • aspirator Z99.0 — Dependence on aspirator
  • care provider (because of) Z74.9 — Problem related to care provider dependency, unspecified
  • impaired mobility Z74.09 — Other reduced mobility
  • need for
  • assistance with personal care Z74.1 — Need for assistance with personal care
  • continuous supervision Z74.3 — Need for continuous supervision
  • no other household member able to render care Z74.2 — Need for assistance at home and no other household member able to render care
  • specified reason NEC Z74.8 — Other problems related to care provider dependency
  • machine Z99.89 — Dependence on other enabling machines and devices
  • enabling NEC Z99.89 — Dependence on other enabling machines and devices
  • specified type NEC Z99.89 — Dependence on other enabling machines and devices
  • renal dialysis (hemodialysis) (peritoneal) Z99.2 — Dependence on renal dialysis
  • respirator Z99.11 — Dependence on respirator [ventilator] status
  • ventilator Z99.11 — Dependence on respirator [ventilator] status
  • wheelchair Z99.3 — Dependence on wheelchair
  • opiate
  • opioids
  • opium (alkaloids) (derivatives) (tincture)
  • oxygen (long-term) (supplemental) Z99.81 — Dependence on supplemental oxygen
  • paraldehyde
  • paregoric
  • PCP (phencyclidine) (or related substance)
  • pentobarbital
  • pentobarbitone (sodium)
  • pentothal
  • peyote
  • phencyclidine (PCP) (or related substance)
  • phenmetrazine
  • phenobarbital

See all 315 entries in the alphabetic index

Common questions about dependence ICD-10 codes

What is the ICD-10 code for dependence?

F19.20 — Other psychoactive substance dependence, uncomplicated. More specific codes apply when the documentation supports them: F19.21, F10.20, F10.26, F10.280 and others below.

What is the ICD-10 code for alcohol dependence?

F10.20 — Alcohol dependence, uncomplicated.

What is the ICD-10 code for analgesic nec dependence?

F55.8 — Abuse of other non-psychoactive substances.

What is the ICD-10 code for combinations of drugs dependence?

F19.20 — Other psychoactive substance dependence, uncomplicated.

What is the ICD-10 code for drug nec dependence?

F19.20 — Other psychoactive substance dependence, uncomplicated.

What is the ICD-10 code for nitrous oxide dependence?

F19.20 — Other psychoactive substance dependence, uncomplicated.

What is the ICD-10 code for oxygen dependence?

Z99.81 — Dependence on supplemental oxygen.

Is F19.20 billable?

Yes. F19.20 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can F19.20 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict F19.20 as a principal diagnosis.

Is F19.20 a CC or MCC?

F19.20 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.