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ICD-10-CM 2027

ICD-10 code for delirium substance-induced

F19.921

Other psychoactive substance use, unspecified with intoxication with delirium

✓ Billable / specificCC — complication/comorbidity

From the official ICD-10-CM alphabetic index entry “Substance (other psychoactive)-induced › delirium”. Page updated September 29, 2026.

About coding delirium substance-induced

The ICD-10-CM code for delirium substance-induced is F19.921 (Other psychoactive substance use, unspecified with intoxication with delirium).

Within F19.92 (other psychoactive substance use, unspecified with intoxication), F19.921 is specifically for other psychoactive substance use, unspecified with intoxication with delirium. Related codes cover uncomplicated (F19.920), with perceptual disturbance (F19.922) and unspecified (F19.929).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 894 (Alcohol, Drug Abuse or Dependence, Left AMA, relative weight 0.6275), DRG 895 (Alcohol, Drug Abuse or Dependence with Rehabilitation Therapy, relative weight 1.4266), DRG 896 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy with MCC, relative weight 1.6617) and DRG 897 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy without MCC, relative weight 0.8584), in MDC 20 (Alcohol/Drug Use and Alcohol/Drug Induced Organic Mental Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Common questions about delirium substance-induced ICD-10 codes

What is the ICD-10 code for delirium substance-induced?

F19.921 — Other psychoactive substance use, unspecified with intoxication with delirium.

Is F19.921 billable?

Yes. F19.921 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can F19.921 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict F19.921 as a principal diagnosis.

Is F19.921 a CC or MCC?

F19.921 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.