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Dx

ICD-10-CM 2027

ICD-10 code for cystic mesothelioma

D48.4

Neoplasm of uncertain behavior of peritoneum

✓ Billable / specific

From the official ICD-10-CM alphabetic index entry “Mesothelioma (malignant) › cystic”. Page updated September 29, 2026.

About coding cystic mesothelioma

The ICD-10-CM code for cystic mesothelioma is D48.4 (Neoplasm of uncertain behavior of peritoneum).

Within D48 (neoplasm of uncertain behavior of other and unspecified sites), D48.4 is specifically for neoplasm of uncertain behavior of peritoneum. Related codes cover behavior of bone and articular cartilage (D48.0), behavior of connective and other soft tissue (D48.1), behavior of peripheral nerves and autonomic nervous system (D48.2), behavior of retroperitoneum (D48.3), behavior of skin (D48.5), behavior of breast (D48.6), behavior of other specified sites (D48.7) and behavior, unspecified (D48.9).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 374 (Digestive Malignancy with MCC, relative weight 2.1109), DRG 375 (Digestive Malignancy with CC, relative weight 1.1838) and DRG 376 (Digestive Malignancy without CC/MCC, relative weight 0.8929), in MDC 06 (Diseases and Disorders of the Digestive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Common questions about cystic mesothelioma ICD-10 codes

What is the ICD-10 code for cystic mesothelioma?

D48.4 — Neoplasm of uncertain behavior of peritoneum.

Is D48.4 billable?

Yes. D48.4 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D48.4 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D48.4 as a principal diagnosis.

Is D48.4 a CC or MCC?

No. D48.4 is neither a CC nor an MCC under MS-DRG v44.0.