ICD-10-CM 2027
ICD-10 code for Cyclosporine long-term drug therapy
From the official ICD-10-CM alphabetic index entry “Long-term (current) (prophylactic) drug therapy (use of) › cyclosporine”. Page updated September 29, 2026.
About coding Cyclosporine long-term drug therapy
The ICD-10-CM code for Cyclosporine long-term drug therapy is Z79.621 (Long term (current) use of calcineurin inhibitor).
Within Z79.62 (long term (current) use of immunosuppressant), Z79.621 is specifically for long term (current) use of calcineurin inhibitor. Related codes cover immunosuppressive biologic (Z79.620), Janus kinase inhibitor (Z79.622), mammalian target of rapamycin (mTOR) inhibitor (Z79.623) and inhibitors of nucleotide synthesis (Z79.624).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 949 (Aftercare with CC/MCC, relative weight 1.123) and DRG 950 (Aftercare without CC/MCC, relative weight 0.7664), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Cyclosporine long-term drug therapy ICD-10 codes
What is the ICD-10 code for Cyclosporine long-term drug therapy?
- Z79.621 — Long term (current) use of calcineurin inhibitor.
Is Z79.621 billable?
- Yes. Z79.621 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z79.621 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z79.621 a CC or MCC?
- No. Z79.621 is neither a CC nor an MCC under MS-DRG v44.0.