ICD-10-CM 2027
ICD-10 code for clinical research investigation admission
Encounter for examination for normal comparison and control in clinical research program
From the official ICD-10-CM alphabetic index entry “Admission (for) › clinical research investigation (control) (normal comparison) (participant)”. Page updated September 29, 2026.
About coding clinical research investigation admission
The ICD-10-CM code for clinical research investigation admission is Z00.6 (Encounter for examination for normal comparison and control in clinical research program).
Within Z00 (encounter for general examination without complaint, suspected or reported diagnosis), Z00.6 is specifically for encounter for examination for normal comparison and control in clinical research program. Related codes cover general adult medical examination (Z00.0), newborn, infant and child health examinations (Z00.1), examination for period of rapid growth in childhood (Z00.2), examination for adolescent development state (Z00.3), examination of potential donor of organ and tissue (Z00.5), examination for period of delayed growth in childhood (Z00.7) and other general examination (Z00.8).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about clinical research investigation admission ICD-10 codes
What is the ICD-10 code for clinical research investigation admission?
- Z00.6 — Encounter for examination for normal comparison and control in clinical research program.
Is Z00.6 billable?
- Yes. Z00.6 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z00.6 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict Z00.6 as a principal diagnosis.
Is Z00.6 a CC or MCC?
- No. Z00.6 is neither a CC nor an MCC under MS-DRG v44.0.