ICD-10-CM 2027
ICD-10 code for antidiuretic hormone syndrome
Syndrome of inappropriate secretion of antidiuretic hormone
From the official ICD-10-CM alphabetic index entry “Antidiuretic hormone syndrome”. Page updated September 29, 2026.
About coding antidiuretic hormone syndrome
The ICD-10-CM code for antidiuretic hormone syndrome is E22.2 (Syndrome of inappropriate secretion of antidiuretic hormone).
Within E22 (hyperfunction of pituitary gland), E22.2 is specifically for syndrome of inappropriate secretion of antidiuretic hormone. Related codes cover Acromegaly and pituitary gigantism (E22.0), Hyperprolactinemia (E22.1), other hyperfunction of pituitary gland (E22.8) and unspecified (E22.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about antidiuretic hormone syndrome ICD-10 codes
What is the ICD-10 code for antidiuretic hormone syndrome?
- E22.2 — Syndrome of inappropriate secretion of antidiuretic hormone.
Is E22.2 billable?
- Yes. E22.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E22.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E22.2 as a principal diagnosis.
Is E22.2 a CC or MCC?
- E22.2 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.