ICD-10-CM 2027
ICD-10 code for adenosine deaminase ADA deficiency
From the official ICD-10-CM alphabetic index entry “Deficiency, deficient › adenosine deaminase (ADA)”. Page updated September 29, 2026.
About coding adenosine deaminase ADA deficiency
The ICD-10-CM code for adenosine deaminase ADA deficiency is D81.30 (Adenosine deaminase deficiency, unspecified). The official index lists 5 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D81.30.
Within D81.3, choose D81.30 (Adenosine deaminase deficiency, unspecified) only when documentation doesn't support a more specific option: severe combined immunodeficiency due to adenosine deaminase deficiency (D81.31), adenosine deaminase 2 deficiency (D81.32) and other adenosine deaminase deficiency (D81.39).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific adenosine deaminase ADA deficiency codes (official index)
- with severe combined immunodeficiency (SCID) D81.31 — Severe combined immunodeficiency due to adenosine deaminase deficiency
- partial (type 1) D81.39 — Other adenosine deaminase deficiency
- specified NEC D81.39 — Other adenosine deaminase deficiency
- type 1 (without SCID) (without severe combined immunodeficiency) D81.39 — Other adenosine deaminase deficiency
- type 2 D81.32 — Adenosine deaminase 2 deficiency
Common questions about adenosine deaminase ADA deficiency ICD-10 codes
What is the ICD-10 code for adenosine deaminase ADA deficiency?
- D81.30 — Adenosine deaminase deficiency, unspecified. More specific codes apply when the documentation supports them: D81.31, D81.39, D81.39, D81.39 and others below.
What is the ICD-10 code for partial adenosine deaminase ada deficiency?
- D81.39 — Other adenosine deaminase deficiency.
What is the ICD-10 code for type 1 adenosine deaminase ada deficiency?
- D81.39 — Other adenosine deaminase deficiency.
What is the ICD-10 code for type 2 adenosine deaminase ada deficiency?
- D81.32 — Adenosine deaminase 2 deficiency.
Is D81.30 billable?
- Yes. D81.30 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D81.30 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D81.30 as a principal diagnosis.
Is D81.30 a CC or MCC?
- D81.30 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.