ICD-10-CM 2027
ICD-10 code for ACTH hypersecretion
From the official ICD-10-CM alphabetic index entry “Hypersecretion › ACTH (not associated with Cushing's syndrome)”. Page updated September 29, 2026.
About coding ACTH hypersecretion
The ICD-10-CM code for ACTH hypersecretion is E27.0 (Other adrenocortical overactivity). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on E27.0.
Within E27, choose E27.0 (Other adrenocortical overactivity) only when documentation doesn't support a more specific option: primary adrenocortical insufficiency (E27.1), Addisonian crisis (E27.2), drug-induced adrenocortical insufficiency (E27.3), other and unspecified adrenocortical insufficiency (E27.4), Adrenomedullary hyperfunction (E27.5), other specified disorders of adrenal gland (E27.8) and disorder of adrenal gland, unspecified (E27.9).
Don't report E27.0 together with the conditions in its Excludes1 note: Cushing's syndrome (E24.-).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
More specific ACTH hypersecretion codes (official index)
- pituitary E24.0 — Pituitary-dependent Cushing's disease
Don't confuse with (Excludes1 for E27.0)
- Cushing's syndrome (E24.-)
Common questions about ACTH hypersecretion ICD-10 codes
What is the ICD-10 code for ACTH hypersecretion?
- E27.0 — Other adrenocortical overactivity. More specific codes apply when the documentation supports them: E24.0.
What is the ICD-10 code for pituitary acth hypersecretion?
- E24.0 — Pituitary-dependent Cushing's disease.
Is E27.0 billable?
- Yes. E27.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E27.0 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E27.0 as a principal diagnosis.
Is E27.0 a CC or MCC?
- E27.0 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.