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422 codes

Manifestation codes

Codes that describe a manifestation of an underlying disease. They can't be reported as the principal diagnosis; code the underlying condition first. Source: Medicare Code Editor (MCE) v44, effective October 1, 2026.

Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Chapter 4: Endocrine, nutritional and metabolic diseases

Chapter 5: Mental, Behavioral and Neurodevelopmental disorders

Chapter 6: Diseases of the nervous system

Chapter 7: Diseases of the eye and adnexa

Chapter 8: Diseases of the ear and mastoid process

Chapter 9: Diseases of the circulatory system

Chapter 10: Diseases of the respiratory system

Chapter 11: Diseases of the digestive system

Chapter 12: Diseases of the skin and subcutaneous tissue

Chapter 13: Diseases of the musculoskeletal system and connective tissue

Chapter 14: Diseases of the genitourinary system

Chapter 16: Certain conditions originating in the perinatal period

Chapter 18: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Chapter 21: Factors influencing health status and contact with health services